AGE and RAGE: Hazardous to the Mind? A plea for translational work

Susana Alicia Galle


The present discussion of AGE and RAGE takes into account two meaning of interest. First, in common discourse, age and rage respectively designate a span of life and an emotion. Second, AGE (Advanced Glycation End-product) and RAGE (Receptor for Advanced Glycation End-product) are the molecular acronyms of age and rage. This article explores their respective influences on health and disease while the focus is primarily on the acronyms. The impact of mental/behavioral factors and lifestyle is considered. Practical ways of AGE assessment in food selection and preparation can be shared with patients. Hypotheses about the mind's role in stimulating or quieting AGE and RAGE are advanced. The dialogue about age (as in "aging"), modulation of negative emotions (anger/rage, etc.), and mind re-direction relative to them, is an integral part of psychotherapy. At present, food choices, eating behavior, and cooking practices can be incorporated into the psychotherapeutic matrix to advocate patients' self-care and advance disease prevention. Acknowledging the mind's role as a generator of health-building or noxious molecular effects necessitates systematic inquiry.


Key words: AGE (Advanced Glycation End-product), RAGE (Receptor for Advanced Glycation End-product), Maillard reaction, anti-glycation, digestive competence, psychotherapeutic matrix, the art of conscious eating.

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